Thrush treatment with clotrimazole in women. What is clotrimazole ointment used for? Release form, composition and mechanism of action

Fungal infections of the skin and mucous membranes are a common dermatological problem that is eliminated with the help of antimycotic agents. One of them is Clotrimazole, a cream and other products based on which effectively fight the symptoms and the root cause of the disease.

Compound

The composition of the cream includes the active ingredient (antimycotic) clotrimazole, as well as excipients:

• water;
• cetyl and stearyl alcohols;
• polysorbate;
• wax esters;
• benzyl alcohol;
• octyldodecanol;
• cetyl palmitate;
• sorbitan stearate.

The concentration of antimycotic in Clotrimazole can be 1% and 2% (10 mg or 20 mg per 1 g of cream, respectively).

Dosage form

Clotrimazole is available in the form of creams with different concentrations of the active ingredient. Alternative dosage forms of the drug are other external agents: vaginal tablets, solution and ointment.

The most convenient form of Clotrimazole for the treatment of skin infections is a cream. It has a lighter texture than an ointment, is well absorbed and creates a layer of an antifungal component on the surface of the affected area. With onychomycosis (nail infection), the cream is usually used to prevent the spread of the process to the skin and healthy plates. Directly for the treatment of a nail infection, a solution of Clotrimazole is more often used.

The cream can also be used in the treatment of genital mycosis (candidiasis, or thrush), but this dosage form is more convenient in the treatment of pathology in men. Women are advised to either combine vaginal tablets with a 1% remedy or use a more concentrated (2%) intravaginal cream with a special dispenser.

The action of the drug

The antifungal effect of the cream is due to the property of clotrimazole to influence the synthesis of an important component of the cell membrane of the fungus. As a result of violation of the electrolytic balance and permeability of the cell wall, it is destroyed. In high concentrations, the antimycotic acts not only fungistatically, stopping infection, but also fungicidal, affecting peroxidase enzymes and increasing the content of hydrogen peroxide in fungal cells to a toxic level.

Clotrimazole inhibits the reproduction of yeasts, molds, dermatophytes, as well as some bacteria and protozoa.

Indications for use

Clotrimazole has quite wide range testimony. It helps patients with diseases such as:

Contraindications

The drug is contraindicated for use in:

• hypersensitivity to the components of the drug (primarily clotrimazole, cetyl and stearyl alcohols);
• menstruation (with infections of the vaginal mucosa);
• pregnancy (1 trimester);
• treatment of newborns, especially premature babies.

In childhood, with allergies to antimycotics of the azole group and during breastfeeding, the drug is prescribed with caution.

With a history of sexually transmitted diseases, fever, pain in the back and lower body, impaired renal function, purulent discharge from the genital organs, bleeding and ulcers of the vulva and vagina, nausea and vomiting, the decision to start or continue therapy should be made by a doctor. Self-medication in these cases is strictly prohibited.

Application rules (instruction)

The cream is applied externally. V individual cases application to mucous membranes affected by a fungal infection may be recommended.

Before starting treatment, you should consult a doctor and undergo a microbiological study to determine the sensitivity of the microflora to the antimycotic. The application of the cream should be regular, long-term and carried out under the supervision of a specialist - self-medication is fraught with the development of a chronic disease.

For adults

Adults need to apply the product to the affected areas 2-3 times a day, gently rubbing. With thrush, the cream is applied to the head of the penis with the foreskin or to the area near the labia and inside the vagina.

With intravaginal use, the drug is administered using a disposable applicator in an amount of not more than 5 g per 1 dose. The procedure is carried out 1 time before bedtime. To distribute the drug throughout the affected area, you need to take a horizontal position and deeply insert the applicator with the medicine.

Before applying the cream, you need to wash the area of ​​application with neutral pH products, in case of dermatomycosis, additionally dry the skin. The use of alkaline hygiene products reduces the effectiveness of Clotrimazole.

The total duration of the treatment course is:

With thrush, treatment must be carried out together with a sexual partner.

For preventive purposes, you need to continue the course for another 2 weeks, even after the disappearance of the external symptoms of the fungus. In the absence of the effectiveness of the cream within a month, therapy must be changed.

For kids

For the treatment of children under 3 years of age, Clotrimazole is not used. At an older age, the decision on the need for therapy should be made by the doctor.

During pregnancy and breastfeeding

Instructions for use indicate the need for medical supervision in the treatment of pregnant women and the prohibition of the use of Clotrimazole in the 1st trimester of gestation.

Intravaginal administration by means of an applicator to pregnant patients is not prescribed. During breastfeeding, the cream should not be applied to the skin of the mammary glands.

Overdose

Due to the low absorption of the drug into the systemic circulation, an overdose is unlikely. The development of a pathological reaction (dizziness, vomiting) is possible with accidental ingestion of the drug, application to a large area of ​​the skin, intravaginal administration in violation of the recommendations on the frequency of repetition of the procedure.

drug interaction

Intravaginal use of Clotrimazole negatively affects the effectiveness of drugs from the polyene group and increases the concentration of tacrolimus and sirolimus in the blood plasma. The antifungal properties of the cream are inhibited by the indicated polyene drugs, as well as Dexamethasone.

The use of Clotrimazole in the genital area reduces the effectiveness of diaphragms and condoms. The use of spermicidal lubricants during the treatment period is undesirable. Drug interaction of Clotrimazole with oral contraceptives has not been recorded.

Adverse reactions

During the use of the cream, the following side effects may occur:

• allergic reactions;
• itching, redness, swelling, rashes, ulceration and soreness of the genitals;
• intercurrent cystitis, increased urge to urinate;
• rarely - fainting, decreased pressure, shortness of breath, headache, stomach ache.

Most side effects occur in cases of intravaginal administration of Clotrimazole, since the mucous membranes absorb from 3 to 10% of the antimycotic into the systemic circulation.

Analogues

Analogues of Clotrimazole cream are:

• Candide;
• Mycotrin (foot cream with clotrimazole and triclosan);
• Canison;
• Kanesten;
• Candibene.

With an intense inflammatory reaction to a fungal infection and the addition of a bacterial infection, drugs with antimycotics, glucocorticoids and antibiotics are prescribed - for example, Candiderm, Beclomethasone or Gentamicin.

Clotrimazole is an affordable and effective drug with a broad spectrum antifungal effect, which is also prescribed for the treatment of vaginal candidiasis.

Available in the form of a solution, ointment, cream, suppositories, tablets. Each form has its own advantages and disadvantages. In the article, we will consider a cream and ointment, instructions for use for women, men, children.

Why use Clotrimazole cream and ointment in the treatment of thrush

The main active ingredient of the drug is imidazole, which can sharply inhibit the formation of pathogenic fungi of the genus Candida, which cause thrush. During the application, the concentration of the active component increases, which leads to a violation of the structure of the cell membranes of pathogenic microorganisms and their inevitable death.

Ointment and cream Clotrimazole is used in the treatment of thrush in women, men and children. In ointment contains more fat, which allows the drug to penetrate much deeper. If thrush in women and men is accompanied by increased dryness of the skin and mucous membranes, then this form is most effective. Application to the affected areas creates a protective layer that prevents moisture from evaporating. At the same time, it has an antifungal effect in the middle layers of the epidermis.

Cream is better to use if there is abundant curdled discharge. In addition to the therapeutic effect, it will have a drying effect. Small concentrations inhibit the growth of pathogenic microflora, large ones cause irreversible processes in the structure of the fungus.

Features of children's candidiasis- diaper rash in the area of ​​\u200b\u200bthe skin masonry - suggest the use of 1% cream.

Thrush is a "family" disease, so the course must be completed by all family members.

Instructions for use of the ointment / cream

The duration of therapy depends on the severity of the disease, the condition of the mucosa and wears individual character. The average course for women, men and children (after 6 years) is 2-4 weeks.

According to the instructions for use of Clotrimazole ointment, it is recommended to apply twice a day, in the morning and in the evening, after the mandatory thorough hygiene procedures using neutral Ph products.

With thrush women a small amount should be rubbed with light movements, spreading over dry, clean skin and the genital area. For vaginal use, a strip 5 cm long is sufficient.

Treatment child Clotrimazole should be carried out with extreme caution, because the skin of children performs an active respiratory function - it cannot be immediately covered over a significant area of ​​the lesion. Apply the same way, twice a day, but in small portions on separate areas.

How to apply to prevent relapse: treatment should be continued after the complete disappearance of the symptoms of the disease within 1-2 weeks.

Contraindications

Clotrimazole ointment / cream should be abandoned in case of individual intolerance to the components and impaired liver function.

Features of the use of Clotrimazole ointment

During treatment, you should refrain from sexual intercourse. If the nature of the disease allows sexual life, then the use of latex contraceptives should be excluded.

Side effects

Undesirable reactions in the treatment of Clotrimazole ointment can be:

• irritation on the skin and mucous membranes;
• swelling;
• redness;
• and pain.

In rare cases, skin rashes and blisters are observed.

Symptoms should not be ignored, if they occur, you should immediately consult a doctor to stop the drug and prescribe an alternative treatment.

Analogues of Clotrimazole

1. Candide Clotrimazole

An antifungal pharmaceutical product that is similar to the agent in question healing effect in relation to thrush, but with a wider spectrum of action.

1. Triderm

Successfully treats urogenital candidiasis and other fungal skin lesions. It has a similar therapeutic result, but differs in the presence of additional active substances.

1. Canison

Combined agent with a pronounced antifungal effect. Effectively used for inguinal candidiasis. At the heart, in addition to clotrimazole, gentamicin (an antibiotic with a wide spectrum of action).

1. Imidil

An antifungal drug that is a derivative of imidazole and triazole. Assign for genital and vaginal infections caused by Candida or Trichomonas. It has a greater number of adverse reactions compared to Clotrimazole.

1. Clotrisal

Consists of clotrimazole and salicylic acid. Assign with thrush to adults and children over 14 years of age.

Similar content

Thrush is one of the most common fungal diseases, which is equally relevant for both women and men. male body. Candidiasis, contrary to popular belief, can affect not only the reproductive organs, in particular the vagina, but also many other systems, even the skin. It is not difficult to cure this ailment today, especially if Clotrimazole is used for thrush.

Among the many antifungal agents that can be found on the shelves of domestic pharmacies, Clotrimazole ointment stands out. This drug has the best combination of price and quality. It is also important that it has little effect on the human body.

Clotrimazole has an optimal combination of price and quality

Compound	Release form	Action
The main active ingredient is clotrimazole. The auxiliary components are: liquid paraffin; soft paraffin; disodium hydrogen phosphate; chlorocresol; cetostearyl alcohol; sodium dihydrogen phosphate; purified water.	If we consider specifically the ointment, then it has a classic consistency for this type of substance. Has white color and opaque structure. There is no smell. Today, an ointment for external use is produced, as well as a vaginal cream. The capacity of the aluminum tube is 20 or 25 g. The lid is equipped with an applicator. The drug is supplied in a dense cardboard package. The active substance of the drug, which is called clotrimazole, is currently considered to be one of the most effective in the fight against various fungal infections, not only yeast, but also dimorphic and moldy. Dermatophytes also demonstrate sensitivity to clotrimazole. It is also known that this substance has an antibacterial effect on corynebacteria (causing diphtheria), as well as on a number of gram-positive cocci. Clotrimazole is poorly soluble in water or ether, but it does it well in chloroform, polyethylene glycol and ethanol, that is, alcohol. Due to its low toxicity, this chemical is actively used to treat fungal diseases found not only in adults but also in children. At the moment, the drug has found its application in gynecology, venereology, obstetrics, dermatology and therapy. Once inside the cell, the active substance leads to the death of its organelles, resulting in cell necrosis. It is important to understand that the fungistatic and fungicidal effect of the drug is directly related to the concentration of the drug. That is, the more it is, the higher the effectiveness of treatment. Clotrimazole ointment for thrush in women is poorly absorbed into the skin Clotrimazole ointment for thrush in women is poorly absorbed through the skin and mucous membranes. Even in the case of vaginal application, the amount of absorbed substance rarely exceeds 10 percent of the total applied mass. However, what is there is enough to successfully fight a fungal infection. Clotrimazole is metabolized in the liver, gradually turning into several types of metabolites. All of them are not active, respectively, do not have any effect on the body, and after a while they are excreted along with the feces. A sufficiently high concentration of the absorbed active substance is observed in the vaginal secretion for several days. In the blood, its content is much less. At the moment, there is no evidence or even prerequisites for the fact that clotrimazole can have a toxic effect on a living organism. Due to its versatility, this drug can be used for effective treatment a range of diseases: candidal vulvitis - the disease affects the vulva; - one of the most common forms of this disease; cutaneous candidiasis - the fungus affects the skin; candidal balanitis - this problem is relevant for men. It is characterized by the development of a fungal colony on the head of the penis; trichomoniasis - it is known that Clotrimazole is effective against the simplest pathogenic microorganisms, which is Trichomonas; other diseases provoked by yeast and yeast-like fungi. Also, this drug can be used to sanitize the vagina, for example, before any operation or before childbirth. As for contraindications, there are not very many of them, especially when compared with other antifungal agents, as well as antibacterial drugs. The main contraindication is increased individual sensitivity to active substance i.e. clotrimazole. Therefore, before prescribing the drug, it is imperative to conduct a test for the presence of an allergy. Cottage cheese discharge with thrush in the vagina A contraindication is the presence in the patient of serious violations of the functionality of the liver. Since the drug is metabolized in this organ, there should not be any problems with it. Otherwise, the processing of the medicinal substance slows down, and its uncontrolled distribution through the bloodstream and, consequently, throughout the body is possible. How to use Clotrimazole cream for thrush for women when it comes to pregnant patients? It is strictly forbidden to use this drug in the first trimester of pregnancy. In the future, treatment with it is possible, but only with the permission of the attending physician and exclusively under his supervision. The use of this dosage form of the drug is very simple. The important thing is that it is not typical for an overdose. However, using half a tube at a time is not recommended, as this will not give an improved result, but will lead to the need to buy another tube. How to use Clotrimazole ointment for thrush in women? Everything is very simple - you need to treat the affected surfaces. The cream is applied in a small layer, twice a day. You don't need to rub anything. If we are talking about vaginal candidiasis (it is not difficult to determine its presence - characteristic curd substances are released from the vagina, and also appears), then in addition to the ointment, it is recommended to use vaginal suppositories in parallel. The same applies if the patient is diagnosed with intestinal candidiasis - in this case, therapy is supplemented with rectal suppositories. Before medical manipulations it is recommended to carry out hygiene procedures - thoroughly wash the area affected by the fungal infection and dry it. The optimal duration of the course of treatment is two weeks, the maximum is four. If after this period the cure for thrush has not occurred, an adjustment in therapy will be required, as well as a short break. The optimal consistency of the ointment allows you to easily apply it to the most difficult areas, including mucous membranes. Treatment is strongly recommended for both partners, and at the same time. Whether candidiasis is found in another person does not matter. Store the drug in a dry and cool place where there is no access to children and animals. Shelf life - three years. Side effects Most observed side effects due to the fact that the patient does not know how to use Clotrimazole ointment for thrush for women. Despite the fact that there will still be no overdose, an individual reaction of the body is possible and, as a rule, it is negative. Classic side effects of this drug include: redness, itching, burning and other phenomena that indicate local irritation may occur at the site of application. The skin may begin to peel off, blisters appear on it, it swells significantly; application in the genital area may cause such side effects like itching, redness, irritation, pollakiuria, soreness during intercourse, hyperemia, burning, incomprehensible vaginal discharge. The bladder may also become inflamed; when used in the oral cavity - swelling of tissues, unpleasant aftertaste, redness, burning sensation; a general allergic reaction - as a rule, it is an itching of the skin, as well as the appearance of characteristic rashes, better known as urticaria. The instruction of Clotrimazole ointment for thrush in women is quite simple and does not require special preparation. Due to this, the drug is successfully used at home. However, you must first consult with your doctor. Only he can prescribe this remedy for you.

But is it worth overpaying hard-earned money, because a wide range of effective and affordable medicines are on sale? One of these medicines is a pharmaceutical product called Clotrimazole. Today's article will be devoted to him.

Let us consider in detail: what is clotrimazole ointment, instructions for use, indications for use, side effects, features of use in childhood, while breastfeeding.

Clotrimazole is an ointment (cream) for external use with a pronounced antifungal effect. The base for the liniment is medical vaseline, thanks to which the prolonged effect of the drug is ensured. The treating, and concurrently, the main active ingredient is clotrimazole, an imidazole derivative.

The synthesized antimycotic drug is used in the etiotropic therapy of infections of fungal etiology. The drug is characterized by a wide spectrum of action, and therefore must be in the first-aid kit.

The action of the liniment is aimed at:

• suppression of the activity of bacteria and fungi;
• complete destruction of pathogenic microflora;
• resistance to the components of the drug is not developed, even with prolonged use.

Only a few strains of Candida are known to be inert to Clotrimazole.

Pharmacological group and action

Clotrimazole ointment is a non-hormonal drug belonging to the antifungal clinical and pharmacological group. The medication is used only externally. The antimycotic action is aimed at preventing the intensive growth, spread of fungal cells, suppression of vital processes.

Clotrimazole acts on the membrane structure of the cell, increasing its permeability Mechanism of influence on pathogenic microflora:

The final effect is determined by the dosage of the main component: a small concentration of clotrimazole prevents the development and spread of the fungus, and high doses of the same element destroy the fungal structure at the cellular level (fungicidal effect). The active substance affects the mitochondria of the fungus, disrupts the sequence of metabolic reactions, which leads to the saturation of cells with hydrogen peroxide. As a result, the cell dies very quickly.

Clotrimazole is characterized by mild antibacterial activity against gram-negative and gram-positive bacteria.

Release form and composition

To date, the drug is produced by several companies located both in Russia and abroad. The drug is sold in several dosage forms:

• ointment (1%) - in aluminum tubes of 15, 20, 25, 30 and 40 g, supplied in cardboard boxes;
• gel (1%) - in aluminum tubes of 20 and 40 g, each of which is in a carton with instructions for use;
• clotrimazole cream (1%)- in aluminum tubes of 15, 20, 30 and 50 g in cardboard packs indicating the date of production, composition and recommendations for application.

For women, vaginal suppositories and clotrimazole tablets are available, but we will devote a separate article to them, but today I would like to dwell on external agents in more detail. It is obvious that the listed dosage forms differ not only in packaging, but also in components.

The composition of preparations based on clotrimazole:

Some pharmaceutical companies produce the drug in granular and powder form, but these are almost non-existent in pharmacies.

Instructions for use clotrimazole cream

The drug Clotrimazole involves exclusively external use, especially when it comes to antifungal therapy. In accordance with the official instructions, the cream is applied 2 to 3 times a day with a thin layer, followed by an even distribution of the composition on the affected areas of the body. Regardless of what the medication is used for, only dry and clean areas of the epidermis are processed.

With serious and extensive fungal skin lesions, ulcers, the use of compresses based on a medicinal cream is indicated. This will saturate the dermis with a large amount of medication, quickly achieve the desired effect.

The duration of the therapeutic course is determined by the attending physician on an individual basis for each patient. Specific terms depend on the effectiveness of the drugs used, the localization of the disease, the severity of the course of the disease.

Indications for use

If you do not know what Clotrimazole ointment helps with, we recommend that you consult a dermatologist before use. The main purpose of the drug is the elimination of pathology and concomitant ailments of fungal etiology.

The medication is prescribed for:

The drug is also prescribed for pathologies accompanied by a bacterial infection, purulent discharge. There are cases when, with the help of clotrimazole, streptoderma and herpes were effectively eliminated. Vaginally, the cream is used before delivery to sanitize the genital tract.

Contraindications and side effects

Liniment is characterized by exceptional tolerability human body. But the use of clotrimazole ointment should be avoided by those patients who have a history of such complications:

• the body's tendency to allergic reactions (hypersensitivity, including skin integuments);
• problems with the functioning of the liver;
• the presence of unhealed or open wounds on the surface of the skin;
• individual intolerance to the components of the drug.

Adverse reactions with dosed local application of the drug are practically not observed. But they should not be completely ruled out. It is mainly about temporary allergic manifestations:

• peeling of the epithelium;
• slight tingling after applying the cream;
• erythema;
• swelling, burning and itching.

To eliminate them, it is enough to refuse to use the ointment and wait from 6 to 48 hours, side effects do not require any treatment.

Many women in the position manifest a pronounced thrush, which is quite expected. Often, during the first trimester, the medication in question is not prescribed. But if a fungal disease (we are talking not only about thrush, but also other fungal infections) is actively progressing, and other drugs are not effective, the doctor can take the appropriate risks.

It is important to note that during pregnancy, Clotrimazole is one of the safest drugs, both for the body of the expectant mother and for the fetus in the womb. It is characterized by a local effect without entering the mainstream of the bloodstream.

When breastfeeding a child, it is better for the mother to refuse to use the medicine, because. its effect on milk has not been studied. Some doctors suggest that the components of the ointment are able to penetrate into it, i.e. be transmitted to the breast.

Application in childhood

Despite the safety and high tolerability of the drug, clotrimazole is contraindicated for children under 12 years of age. This is due to the lack of relevant clinical studies. However, on the appointment of a pediatrician and under his supervision, the use of liniment in short courses is allowed.

Dosage and administration

Many patients do not know how to use the medication to treat a particular ailment. Below are the universal ways of using the drug with an indication of the average doses for each procedure. Dermatologists focus on the need to continue therapy (for 1.5-2 weeks) in cases where the symptoms of the disease have completely disappeared, the doctor cancels the ointment after the patient has completely recovered.

• Fungal lesions of the genital organs(thrush, etc. for men and women) - the affected areas of the skin are treated 2 to 3 times a day. The average dose is 1-2 mm ointment for external application. The composition is lightly rubbed into the problem area, underwear is worn only after it is completely absorbed into the skin. The duration of therapy is until the complete disappearance of painful symptoms.
• Dermatomycosis - 1-3 mm ointment is applied to the affected areas 2 times a day. Treatment lasts from 2 to 4 weeks, if we are talking about multi-colored lichen - no more than 3 weeks.
• Vaginal cream applied in a similar way. The optimal daily dosage for the skin and mucous membranes is 5 g / 1 pr. The frequency of repetition is 1 time per day. The duration of therapy is 3 days.

The body of each person is individual, as well as the characteristics of the course of the pathology, and therefore it is important to coordinate each step with the doctor, strictly adhere to his recommendations, and comply with the prescribed doses.

special instructions

Before applying the drug, you must read the instructions for use, which provides for a number of special instructions:

• Clotrimazole gel according to the mechanism of action fully corresponds to the ointment, its main difference is a convenient form for treating hard-to-reach places. The gel is able to be evenly distributed and quickly absorbed into the skin.
• Liniment is contraindicated in infants, during lactation it is better to refrain from using the agent in question.
• When applying the composition, it is important to exclude contact with the mucous membrane of the eyes, the adjacent area.
• For the period of treatment of thrush, it is necessary to refrain from sexual relations for both partners.
• The cream should not get into open wounds.

If the slightest mistake is made when using the drug or an allergic reaction occurs, you should consult a doctor and stop drug therapy.

Clotrimazole instruction

Instruction Clotrimazole gives Full description the drug Clotrimazole, presenting it as an antifungal medicine for outdoor use.

Clotrimazole release form

The drug Clotrimazole has several forms of release. On pharmacy shelves it can be found in the form of ointment, cream, suppositories and solution.

Clotrimazole composition

Clotrimazole ointment composition

Ointment for external use. Represents a mass white color uniform consistency.

The active substance is clotrimazole. Auxiliary substances in the required proportions of propylene glycol, polyethylene oxide 1500, polyethylene oxide 400, nipagin or methyl paraben.

Clotrimazole cream composition

Cream for external use. It is a homogeneous mass of white color.

The active substance is clotrimazole. Excipients in the required proportions of benzyl alcohol, cetostearyl alcohol, octyldodecanol, polysorbate, sorbitan stearate, synthetic spermaceti, and water.

Clotrimazole suppositories composition

The drug is in the form of vaginal suppositories having a cylindrical-conical shape. The color is white or with a yellow tint.

The active substance is clotrimazole. Auxiliary substances in the required proportions of semi-synthetic glyceride.

Clotrimazole solution composition

The preparation has a soft consistency like an emulsion. White colour.

The active substance is clotrimazole. Excipients in the required proportions of liquid paraffin, ketosteryl alcohol, white soft paraffin, ketomacrogol 1000, purified water, chlorocresol, disodium edetate, citric acid, dibasic sodium phosphate, propylene glycol, sodium metabisulphite.

Storage conditions

The drug must not be frozen. You can store for three years from the date of manufacture. The storage room should be inaccessible to children with an air temperature not exceeding 25 degrees.

Pharmacology

The drug Clotrimazole refers to antifungal agents that have a wide spectrum of action. Applied locally. The effectiveness of its antifungal action is based on the ability to disrupt the synthesis of ergosterol, which is part of the fungal cell membrane.

Clotrimazole activity extends in relation to dermatophyte, yeast-like and mold fungus, as well as to the causative agent of multi-colored lichen (Pityriasis versicolor) and the causative agent of erythrasma. Clotrimazole is capable of exerting antimicrobial activity against gram-positive (Staphylococcus, Streptococcus) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.

Indications for use Clotrimazole

Clotrimazole indications for use (ointment)

Clotrimazole ointment is indicated for external use in the following cases:

• With fungal diseases of the skin;
• With mycoses of the foot or skin folds;
• With pityriasis versicolor;
• With erythrasma;
• With superficial candidiasis, which are caused by a dermatophyte, yeast (Candida), mold and other fungus or a pathogen that is sensitive to clotrimazole;
• With mycoses, which are complicated by secondary pyoderma.

Candles (tablets) Clotrimazole indications for use

The drug Clotrimazole in the form of suppositories and vaginal tablets is intended for the treatment of vaginal infections in girls and women, which are caused by a yeast-like fungus of the genus Candida. Also, the indications apply to superinfections that can cause microorganisms sensitive to the drug.

clotrimazole cream indications

The drug Clotrimazole in the form of a cream is used to treat skin fungus and is indicated for use in the following conditions:

• With mycoses of the foot, hand, trunk, skin folds;
• With candidal vulvitis,
• With candidal balanitis;
• In the presence of multi-colored lichen,
• With erythrasma;
• With a fungal infection in the outer ear.

clotrimazole solution indications

The drug Clotrimazole in the form of a solution is used to treat fungus-affected skin and mucous membranes. The drug is indicated for use:

• With mycoses of the foot, hand, trunk, lower extremities, skin folds, as well as the area where the beard and mustache, scalp,
• With pityriasis versicolor;
• With erythrasma;
• With candidiasis of the skin, mucous membranes and genitals;
• With paronychia.

Clotrimazole contraindications

The use of the drug Clotrimazole is contraindicated in the first three months of pregnancy, as well as in case of sensitivity to the components that make up the drug.

Clotrimazole instructions for use

Clotrimazole instructions for use ointment / cream

1. The drug is used exclusively externally.
2. On the affected area of ​​the skin after its preliminary cleaning, the ointment / cream is applied not in a thick layer and rubbed with caution. This should be done three times a day.
3. The duration of the course depends on the severity of the disease and the effectiveness of the treatment.
4. Dermatomycosis should be treated with ointment for at least a month.
5. Pityriasis versicolor must be treated for at least three weeks.
6. Fungal lesions on the legs should be treated within two weeks after the symptoms of the disease have been eliminated.

Clotrimazole instructions for use suppositories / tablets

1. The drug in the form of suppositories or vaginal tablets is used exclusively topically.
2. The drug is used only by women intravaginally.
3. V evening time in the supine position, the patient is injected into the vagina 1 suppository.
4. The duration of treatment is six days, 1 suppository / tablet.
5. You can repeat the course of treatment only as prescribed by a doctor.

Clotrimazole solution instructions for use

• The drug Clotrimazole in the form of a solution is used for external treatment, both in adults and in children.
• Apply a small amount of Clotrimazole solution to previously cleaned dry lesions and rub gently into the skin. Apply twice a day. After elimination of the expressed symptoms, use the drug for another month.
• Treat ringworm of the foot for at least two weeks after the symptoms of the lesion disappear. It is desirable to apply the solution after each water procedure.

Clotrimazole for children

The drug Clotrimazole is not prohibited for use in children. However, elementary caution should be exercised when applying the drug to the delicate skin of the baby. In addition, large areas of the skin should also not be covered with the drug, since it also performs a respiratory function for the child.

Clotrimazole during pregnancy

Since it is undesirable for a pregnant woman to insert an applicator into the vagina, it is not advisable to use the drug during the second half of pregnancy, although it does not adversely affect the fetus. But the first three months of pregnancy, the use of the drug is prohibited.

There is no information on the penetration of the drug into breast milk. Therefore, it is better not to use it during breastfeeding.

clotrimazole side effects

As a rule, side effects on the use of the drug do not appear, however, local irritations in the form of itching or burning, as well as allergic reactions, can sometimes occur.

Additional instructions

Do not apply the drug to the skin around the eyes.

In the event that after a month the treatment does not give any positive results, then it should be stopped and examined in order to clarify the diagnosis.

With the development of an allergic reaction or local irritation, treatment should be discontinued and replaced with another one.

Drug Interactions

A high concentration of the propyl ester of para-hydroxybenzoic acid is capable of enhancing the effect of the drug Clotrimazole.

High doses of Dexamethasone can inhibit the action of Clotrimazole.

The drug itself is able to reduce the effect of polyene antibiotics (nystatin, natamycin, amphotericin) with simultaneous use.

Clotrimazole analogues

The drug Clotrimazole has analogues for all its forms of release.

clotrimazole price

The drug has a low price, which ranges from 50 to 100 rubles, depending on the form of release of the drug.