Nowadays, OC (oral contraceptives) are considered the most popular types of contraceptives. For many women, app is the only way out of such an intimate position, since they are not harmful to health, like an "umbrella" or means for use inside the vagina. However, any interference with the body's biological clock can lead to negative consequences.

Janine as a contraceptive

Such app as Janine were created for treatment, and only in the second case, to protect against unwanted pregnancy. When women take Janine, their breasts are enlarged, menstruation is normalized, cysts and formations on the ovaries disappear. There is also noticeable improvement in the second phase of the menstrual cycle if a woman has problems conceiving. Janine is prescribed for hormonal imbalance and for imperfect work of the egg follicle.

As a contraceptive, Janine is well tolerated by women who have not given birth. This can replace them with more strong drugs... Consequences when taking Janine:

• Breast enlargement
• Weight gain (up to 10-12 kg).
• Normalization of the menstrual cycle.

Janine, like any contraceptive, has Negative influence on the reproductive function of a woman. After long-term use (more than 8 months), the work of one of the ovaries may "fail" in a woman. This is manifested in the following:

• Delayed menstruation 8-9 months after starting contraception.
• Profuse leucorrhoea.
• Complications during conception of a child (required from 2-5 months).
• My chest hurts at night.
• Pain in the lower abdomen appears.
• Hair fall out.

With prolonged use of escapel, postinor, zhanin, it is recommended to undergo a gynecologist's examination - there is a chance of getting into the risk zone for infertility patients.

Chest pain after discontinuation of approx.

Why does the female breast react sharply to changes in the body after the abolition of the app? Each of the contraceptives contains a hormonal set of substances that stimulate the breast and mammary glands in general. At a certain point, your body stops receiving "nourishment", and you feel pain - it appears immediately after the abolition of the app, because the cells do not receive that portion of the hormones on the basis of which all the work of the reproductive function took place over the past six months. The body protected itself from the penetration of spermatozoa, and was abruptly left without a "protector", without additional hormones, which it now needs to produce on its own.

As a result, if the body "weaned" from independent production, then it will not be able to be responsible for the malfunctioning of the breast, ovaries and organs involved in fertilization. Under such circumstances, the chest can hurt due to the lack of auxiliary microorganisms. In this case, it is observed:

• Decreased work of the fallopian tubes with contraction.
• Changes in the composition of blood and cervical mucus.
• A change in the structure of the endometrium (which is detrimental to a woman).
• The inability of the uterus to carry a child.

When working on an artificial hormone, the entire reproductive function of a woman is reduced to zero. When treating infertility, it is necessary to select such drugs that will not aggravate the situation.

Urgent contraceptives and their features

When using urgent ok, escapel, and other drugs, the ovaries are not inhibited. On the contrary, under the influence of hormones (with a single use) available in contraceptives, female organs are strenuously fighting "unnecessary" foreign bodies. The body protects itself in advance by activating the ovaries, which causes untimely menstruation. In this case, the chest, lower abdomen, head may hurt.

After the abrupt withdrawal of contraceptives, the work of the ovaries can increase significantly. Hence, severe pain in the gland, sometimes in the back. Among urgent contraceptives, there are those that are suitable for different phenotypes of women:

After stopping the use of postinor, escapel and other urgent medications, at least 4 weeks should pass. It is not recommended to use them every month, as they violate the biological stage of menstruation, also cause pain and discomfort with subsequent menstruation.

When using postinor and escapel, more often 1-2 times a month, a woman, even after stopping use, develops thrush and fungus in the genitals.

After stopping the use of postinor, escapel and other contraceptives, the size of the glands is not restored. This threatens the development of mastitis when feeding a child, cancer, benign tumors. In the absence of a "set" of artificial hormones, the body "sees an excess", stops working and provides all the conditions for conception. "You wanted protection, you will get the natural production of anti-stress by the body."

Consequences of abrupt withdrawal from drugs

In addition to the main problems of stopping the use of escapel, postinor, coco and janine preparations, consequences may develop - a delay in the menstrual cycle, which will not work without the "help" of contraceptives. Probably the development of amenorrhea, when menstruation disappears altogether, regardless of age or pregnancy. If the girl has not yet given birth, she will feel severe pain, spasms. Often they are manifested in those girls who used cook and cook containing drugs.

Combined drugs are not directed at the individual organism, as a rule, they are selected by the women themselves. A doctor, and only a doctor, must prescribe the use of coca, postinor, esapel, since everything must correspond to the phenotype of the organism, the structural features of the uterus, tubes, etc. If at the same time there is pain and spasms of a sharp nature, you need to check the genitals for the presence of pathologies.

There is a high probability of the development of pathologies in the following:

• Gonorrhea.
• Syphilis.
• Hepatitis.

There is a chance of developing the disease thyroid gland... In order not to provoke the consequences, not to cause pain when you stop taking postinor and escapel, you need to stop using them at the end or beginning of the cycle, not in the middle.

I have always been sure that I will never drink contraceptives. I believe that there is no need to interfere with the harmony of the female body, especially the body of a healthy woman. It is our hormones, our feminine essence, the cycle and all this is such a connection between women and nature. I feel it this way, some kind of animal nature, instincts, etc. I never wanted to interfere with these processes.

But it so happened that I was prescribed a life-long appointment with Zhanin.

To say that I was upset is to say nothing. I was afraid of these pills as poison.

It took 17 months of admission. Here are my impressions.

1. The first three packs made me sick at night. I drank them at night and immediately went to bed, but exactly six hours later, every night, I woke up with nausea. Then it passed. Now I feel a little sick on the first pills from the pack. And in the daytime there was a feeling that I was under something, such a sluggish state of prostration.

2. The chest is harder, hurts, increased by half the size, but it would be better if it did not hurt and was as before. Those who drink such preparations for breast augmentation, good luck to you, of course, but you are walking on thin ice.

3. Acne has not gone away. I have pimples on my chin, they have not gone anywhere. The skin has not improved.

4. The weight remains the same. Cellulite, which I have never had, is not strong, but unpleasant, I weigh 52 kg and always wore a thong, and then there are signs of cellulite.

5. Spider veins on the thighs, veins show through, troxerutin does not help. Even on the face, the vessels have become more pronounced. This is, by the way, irreversible changes, this is not for you to knead cellulite.

6. The desire for intimacy did not disappear, I was afraid of it more than cellulite :) This is still a big plus. Of course, it is not the same as before the appointment, but it did not particularly affect my personal life. Although, of course, it cannot be compared with what was before.

7. Nerves remained as they were. It seems to me that those who say that hysteria has begun and strong drops are winding themselves up more. At the expense of emotions, as you tune in, you will feel yourself.

9. Pregnancy does not occur, if this is a plus, then a plus, I just do not think that protection is worth the health consequences that I write about above.

10. Crete days have become small, 3-4 days.

11. Palpitations, tachycardia, especially on the first pills from a new pack, sometimes it is even difficult to fall asleep.

12. I began to drink not at night, but in the morning and the problem with falling asleep went away.

13. Dry eyes. I did not understand why some people who wear lenses cannot take coke, now I understand, really dry eyes. I drip drops of "Slezin" and use Korneregel.

14. Sometimes after exposure to the sun a red rash appears and my hands itch, I was warned about this, I use sunscreen.

15. Microflora, of course, is also not happy with such hormonal effects. I periodically restore it with my beloved Vagilak.

And in this photo my spider thigh is saying hello to the reader.

Pros. This is a chance, really a chance to preserve their reproductive organs for those who are not entirely healthy, do not miss it. Get medical treatment and do not be afraid. Get medical treatment. Do not enlarge breasts and remove acne or condoms you are tired of, get treated.

Ask me if I would drink pills for the sake of protection - NEVER !!! If you are healthy, rejoice and live your natural background and enjoy it. Others no longer have this opportunity.

PS. If you want sex, put on a condom. If you don't want a condom, you don't want sex :)))

Janine is a low-dose oral contraceptive commonly used to prevent pregnancy. Also, the drug can be used for therapeutic purposes, in particular, to reduce the severity of premenstrual syndrome, to treat acne, etc. Is it safe to use the remedy for mastopathy, will it help or harm?

Janine includes two components - ethinylestradiol and dienogest. This is a monophasic drug, which means that each tablet contains the same amount of active ingredient. Normally, the concentration of estrogens and gestagens in the body is constantly changing, and the constant intake of certain concentrations with Zhanin's tablets stimulates restructuring.

That is why, for some (usually no more than 2 - 3 months) time, a woman may experience spotting spotting.

Ethinylestradiol is estrogen and dienogest is progestogen. Due to the dual composition of the tablets, an artificial hormonal background is formed in a woman, which leads her endocrine system into a kind of balance. This is especially noticeable if earlier the girl had malfunctions - delays or periodic daubs.

The drug contains 0.03 mg ethinylestradiol and 2 mg dienogest. These are small doses of hormones, so Janine belongs to low-dose contraceptives. But even such concentrations, some doctors are wary of prescribing for mastopathy, believing that estrogens can increase the manifestations of the disease.

However, there is no reliable scientific data on this, and the temporary enlargement of the mammary glands and slight soreness and discomfort disappear in 2 to 3 months (this does not happen for everyone, as a rule, if the remedy is not completely prescribed). Already after 6 months of admission, the picture of mastopathy significantly improves and the risk of developing breast cancer decreases.

Zhanin's contraceptive effect is due to the influence on the following mechanisms:

• Under the influence of active substances, ovulation is suppressed at the level of the hypothalamus and pituitary gland according to the feedback principle (they stop synthesizing their hormones in the presence of estrogens and gestagens from the outside).
• Cervical mucus becomes thicker, due to this, it is much more difficult for sperm to penetrate into the uterine cavity.
• There are changes in the endometrium (its thinning), which makes it impossible to implant the ovum even during fertilization.

Zhanin's influence on mastopathy and other processes in the body

The therapeutic effect for mastopathy and in general in the presence of some kind of pathology can be observed only with regular and sufficiently long-term administration of Zhanin (at least 3 months). The positive effect on the mammary glands is reflected in the following:

• Continuous use of an oral contraceptive creates relatively stable concentrations of estrogens and gestagens in a woman's blood. This entails stabilizing the connections between the hypothalamus, pituitary gland and ovaries. As a result, proliferative changes in the mammary glands are not so active, which give foci of mastopathy. Areas of uncontrolled growth and education no longer appear, etc.
• If a woman has a high level of estrogen in the blood, with regular intake, its values ​​decrease slightly. And estrogens are the most active stimulators of cell growth, including foci of mastopathy.
• Against the background of long-term use of contraceptives, all inflammatory processes in the appendages, the uterine cavity fade away, cystic formations go away,. All these diseases also contribute to the development of mastopathy.

It is reliably known that taking a contraceptive correctly selected in a given clinical situation already within a year reduces the likelihood of a woman's mastopathy by 50-60%.

If Janine is correctly selected for a particular woman, you can expect the following effect from him after 6 to 12 months of taking:

• The likelihood of contracting breast cancer is halved. Moreover, the longer the reception, the greater the protection. After the end of the use of Janine, the effect will persist for another 10 years.
• With the help of an oral contraceptive, you can remove the symptoms of PMS, including those associated with the mammary glands - swelling, soreness.
• The rate of progression of both the nodal and diffuse form mastopathy.

However, it should be emphasized that all these effects will not always be observed, but only with a correctly selected contraceptive.

Watch the video about mastopathy:

Contraindications for use and possible complications of Zhanin

Janine affects not only the mammary glands, but also the entire body. The thing is that sex hormones are responsible for many functions - for the elasticity of blood vessels and blood coagulability, for the amount of secretion secreted on the mucous membrane of the eyes, internal organs etc. Therefore, when taking Zhanin, in addition to the expected effect (protection against pregnancy), it is possible to develop side reactions that are associated precisely with its systemic action.

The main ones include the following:

• decreased libido and decreased secretion of mucus in the vagina;
• increased risk of thrombosis and thromboembolism;
• the occurrence of headaches and migraines;
• mood swings;
• problems in wearing contact lenses due to increased dryness of the surface of the eyes;
• indigestion and some others.

If such adverse reactions occur, you should stop taking the drug and consult a doctor.

To avoid the unpleasant consequences of using the product, the indications for its use should be strictly observed. In the following cases, it is better to refrain from taking Janine:

• If a woman has ever had thrombosis, thromboembolism and similar conditions (heart attack, stroke, etc.).
• In the case when migraine attacks were recorded once, even if they do not bother for a long time.
• Pathology of the liver, pancreas.
• Diabetes.
• Uncontrolled arterial hypertension.
• Pregnancy and lactation.
• Ever identified hormone-dependent tumors of the genital or other organs.
• Intolerance to the components of the drug.
• Prolonged immobility (after injuries, fractures, etc.).

Benefit and possible harm from taking Zhanin, only a doctor can most reliably assess, therefore, the drug should be used only on his recommendation.

Janine with mastopathy: is it worth taking?

Janine might be enough effective remedy in the fight against mastopathy. But it is not suitable for all women. It should also be understood that by drinking only Janine, it is hardly possible to immediately achieve quick and significant results. For the future, yes, it is good, but in order to quickly remove all the symptoms of mastopathy and stop the progression of pathology, it is better to use complex schemes.

It is optimal if they include, in addition to contraceptives, phytopreparations (such as Mastodinon, and others), as well as immunomodulating and stress-increasing agents.

It is also necessary to understand that in some cases, treatment with any drugs, including oral contraceptives, is initially impractical. For example, this applies to nodular forms, especially large fibroadenomas, which should be surgically removed.

Therefore, the treatment should be prescribed by a doctor, taking into account the woman's health status and the clinical situation.

Zhanin's cost in pharmacies

The cost of the drug depends on the city, the category of the pharmacy and the number of tablets in the package.

The minimum price for one blister varies within 1000 rubles (from 870 to 997). It is more profitable to buy a larger quantity at once, for example, 63 tablets - for three months. The average cost of such a package is in the range of 2200 - 2300 (from 2000 to 2600).

You can also purchase full analogues of a medicine from another manufacturer. For example, Silhouette has a complete identity in composition and action. It costs an order of magnitude cheaper - from 600 rubles for 21 tablets to 1,500 for 63.

Janine is a low-dose, monophasic oral contraceptive used in most cases for contraceptive purposes. Long-term and regular use of the drug with reliable efficacy reduces the risks of breast cancer and the degree of progression of mastopathy in women.

Breast pain and Janine

Asks: Alexandra, Krasnodar

Gender Female

Age: 29

Chronic diseases: not specified

Hello, I was 29 last year on an ultrasound of the breast, they wrote a fatty involution, they said it’s not scary, within a year I am being treated for adenomyosis of the uterus with endometrial hyperplasia, first I drank duphaston for six months from 16 to 25 days, after that Janine was prescribed according to the scheme 21/7 first for three months, now the treatment has been shed for 3-6 months, in principle, it helps a lot in gynecology, but the pills hurt my chest, not so much pain, but it hurts six months ago I was at the oncologist-mammologist looked at the previous ultrasound scan I felt my chest said that everything I did not prescribe a good treatment, I said the reaction to the drug (then I saw dyufaston) and PMS, when I drank Janine for the first three cycles, there was a break in taking the drug, one cycle the doctor said to drink it again, I started drinking it again from the first day of the cycle, together with this I was prescribed a time factor, my chest also aches a little, even a little less than in the first three cycles of taking zhanin before the break and always subsides by the beginning of menstruation, practically passes, and then ova begins to hurt somewhere closer to the middle of taking the pills somewhere around 10-12 days. The breast is soft to the touch. The doctor says that this is a variant of the norm, the body gets used to it again because there was a break. I noticed that with vitamins I seem to be less worried. The gynecologist also said that the period of adaptation to the drug of 3-6 months is the norm. And she also said that it would also be good for the fatty involution of Janine, since she is also treated with hormones in young women, although it is not particularly considered a pathology, but breast ultrasound can be done
Tell me, is it really like that, and there is such an adaptation? And is it possible to drink Janine with fatty involution? Will Jeanine harm the condition of the mammary gland or lead to some nasty in the breast? Thanks in advance!

4 answers

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Hello!
Tell me, is it really like that, and there is such an adaptation?- this really happens, because hormones affect the mammary glands. You rightly noticed that vitamins A and E are good here to reduce pain, so you can add them to your treatment. Here you can also add "Mastodinon".
Will Jeanine harm the condition of the mammary gland or lead to some nasty in the breast?- Yes, oddly enough, it will have a beneficial effect on the course of mastopathy. It will not work if you drink in moderation, and not all your life.

Alexandra 2017-10-11 16:20

Hello Alexey Alexandrovich! Thanks for the quick response! You have calmed me down a little. Only I did not understand a little, no one diagnosed me with mastopathy, the ultrasound doctor wrote a fatty involution, and explained that this is not scary and it happens, sometimes due to hormonal imbalance and sometimes from the fact that the mammary gland was initially so laid down and has such a structure and that, as such, it is not even considered a pathology, otherwise she said that the norm, the uzist also said that there is a little more glandular tissue in the left mammary gland than in the right one, and what is interesting is that my left one is initially a little larger than the right one by a size somewhere plus minus and it is the left one that hurts more, can this be due to the fact that there is more of this glandular tissue and it reacts more to the drug or is it definitely mastopathy? And the gynecologist said that with fatty involution in young women, hormones are also used and Janine should not harm the breast, but on the contrary, I get on the ultrasound only the next month, but it's so scary to be honest. Alexey Alexandrovich would like to know your opinion about the explanations given to me, whether this could be. Maybe I'm panicking in vain. Thank you in advance for your reply and sorry for a lot of text!

Could this be due to the fact that there is more of this glandular tissue and it reacts more to the drug, or is it definitely mastopathy? - you must understand that the growth of glandular tissue and its replacement with fatty tissue occurs only for 2 reasons. 1 - Age (after 45 years), therefore, women are recommended to undergo mammography, 2 - Mastopathy, especially in women who have not been nursing or breastfeeding. There is nothing terrible in mastopathy, it is a benign disease and is treated conservatively, or you can give birth.
Alexey Alexandrovich I would like to know your opinion on the explanations given to me, could this be?- as I wrote to you earlier, this can be, but the doctor did not explain to you very clearly and clearly why this could be. Now you know what "you know is armed" means. Hormones are also used in the treatment of world involution, if you do not want to give birth and do not plan in the future.
Maybe I'm panicking in vain?- oh, how in vain, do not even think to go for explanations on the Internet, you will break your head and you will shed tears. :)

Thank you very much! I will not go online anymore, :-) there are really some horror stories

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In this article, you can read the instructions for using the contraceptive drug Janine... The reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Janine in their practice are presented. A big request to more actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, which may not have been declared by the manufacturer in the annotation. Zhanin's analogs in the presence of available structural analogs. Contraceptive use in healthy women. Side effects(bleeding, pain), as well as during pregnancy while taking the drug.

Janine- low-dose monophasic oral combined estrogen-gestagenic contraceptive drug.

Zhanin's contraceptive effect is carried out through complementary mechanisms, the most important of which are the suppression of ovulation and the change in the viscosity of cervical mucus, as a result of which it becomes impermeable to sperm.

If used correctly, the Pearl index (an indicator reflecting the number of pregnancies in 100 women taking a contraceptive during the year) is less than 1. If pills are missed or misused, the Pearl index may increase.

Zhanin's gestagenic component - dienogest - has antiandrogenic activity, which is confirmed by the results of a number of clinical studies. In addition, dienogest improves the lipid profile of the blood (increases the amount of high density lipoprotein).

In women taking combined oral contraceptives, the menstrual cycle becomes more regular, painful periods are less common, the intensity and duration of bleeding decreases, as a result of which the risk of developing iron deficiency anemia decreases. In addition, there is evidence of a reduced risk of endometrial and ovarian cancer.

Pharmacokinetics

After oral administration, dienogest is rapidly and completely absorbed from the gastrointestinal tract. Dienogest is almost completely metabolized. An insignificant part of dienogest is excreted by the kidneys unchanged. Metabolites are excreted in urine and bile in a ratio of about 3: 1.

After oral administration, ethinyl estradiol is rapidly and completely absorbed. It is not excreted unchanged from the body. Ethinyl estradiol metabolites are excreted in the urine and bile in a ratio of 4: 6.

Indications for admission

• contraception.

Forms of issue

Dragee 2mg + 30mcg (not available in tablet form).

Instructions for use and dosage regimen

Dragee should be taken orally in the order indicated on the package, every day at about the same time, with a little water. Janine should be taken 1 tablet a day continuously for 21 days. Reception of each subsequent pack begins after a 7-day break, during which there is withdrawal bleeding (menstrual bleeding). It usually begins on the 2-3rd day after taking the last tablet and may not end until the start of taking a new package.

Beginning of taking Zhanina

In the absence of taking any hormonal contraceptives in the previous month, Zhanin's intake is started on the 1st day of the menstrual cycle (i.e., on the 1st day of menstrual bleeding). It is allowed to start taking it on the 2-5th day of the menstrual cycle, but in this case it is recommended to use a barrier method of contraception during the first 7 days of taking pills from the first package.

When switching from combined oral contraceptives, a vaginal ring, a transdermal patch, Zhanin's intake should be started the next day after taking the last active tablet from the previous package, but, in no case, no later than the next day after the usual 7-day break in taking (for drugs containing 21 tablets) or after taking the last inactive tablet (for preparations containing 28 tablets per package). When switching from a vaginal ring, a transdermal patch, it is preferable to start taking Zhanin on the day the ring or patch is removed, but no later than the day when a new ring is to be inserted or a new patch is glued on.

When switching from contraceptives containing only gestagens ("mini-pills", injectable forms, an implant) or from a gestagen-releasing intrauterine contraceptive (Mirena), a woman can switch from taking "mini-pills" to Janine any day (without interruption), with an implant or an intrauterine contraceptive with a gestagen - on the day of its removal, from an injectable contraceptive - on the day when the next injection is to be made. In all cases, it is necessary to use an additional barrier method of contraception during the first 7 days of taking pills.

After an abortion in the 1st trimester of pregnancy, a woman can start taking the drug immediately. In this case, the woman does not need additional methods of contraception.

After childbirth or abortion in the 2nd trimester of pregnancy, it is recommended to start taking the drug on the 21-28th day after childbirth or abortion in the 2nd trimester of pregnancy. If the reception is started later, it is necessary to use an additional barrier method of contraception during the first 7 days of taking pills. However, if a woman has already had a sex life, pregnancy should be ruled out or it is necessary to wait for the first menstruation before taking Janine.

Reception of missed pills

If the delay in taking pills is less than 12 hours, contraceptive protection is not reduced. The woman should take the missed pills as soon as possible, the next pills are taken at the usual time.

If the delay in taking the pills is more than 12 hours, contraceptive protection may be reduced.

In this case, you can be guided by the following two basic rules:

• taking the drug should never be interrupted for more than 7 days;
• to achieve adequate suppression of the hypothalamic-pituitary-ovarian system, 7 days of continuous intake of pills are required.

Accordingly, if the delay in taking active pills is more than 12 hours (the interval since taking the last active pills is more than 36 hours), the following can be recommended:

The first week of taking the drug

It is necessary to take the last missed pills as soon as possible, as soon as the woman remembers this (even if for this you need to take two pills at the same time). The next tablet is taken at the usual time. Additionally, a barrier method of contraception (for example, a condom) must be used for the next 7 days. If intercourse took place within a week before skipping the pills, the likelihood of pregnancy must be taken into account. The more dragees are missed, and the closer they are to the break in taking active substances, the more likely it is to become pregnant.

The second week of taking the drug

It is necessary to take the last missed pills as soon as possible, as soon as the woman remembers this (even if for this you need to take two pills at the same time). The next tablet is taken at the usual time. Provided that the woman took the pills correctly within 7 days preceding the first missed pills, there is no need to use additional contraceptive measures. Otherwise, as well as when skipping two or more pills, you must additionally use barrier methods of contraception (for example, a condom) for 7 days.

The third week of taking the drug

The risk of pregnancy is increased due to the upcoming break in taking pills. A woman must strictly adhere to one of the following two options. Moreover, if within 7 days preceding the first missed pills, all pills were taken correctly, there is no need to use additional contraceptive methods.

1. It is necessary to take the last missed pills as soon as possible, as soon as the woman remembers this (even if for this you need to take two pills at the same time). The next pills are taken at the usual time, until the pills from the current package run out. The next pack should be started immediately without interruption. Withdrawal bleeding is unlikely until the second pack ends, but spotting and breakthrough bleeding may occur while taking pills.
2. A woman can also interrupt taking pills from the current package. Then she must take a break for 7 days, including the day of skipping the pills, and then start taking a new package.

If a woman missed taking pills, and then during a break in taking she does not have withdrawal bleeding, it is necessary to exclude pregnancy.

If a woman has vomiting or diarrhea within up to 4 hours after taking active pills, absorption may not be complete and additional contraceptive measures should be taken. In these cases, you should be guided by the recommendations when skipping pills.

Changing the day of the start of the menstrual cycle

To delay the onset of menstruation, a woman should continue taking pills from a new Zhanin package immediately after all pills from the previous one have been taken, without interruption. Dragee from this new package can be taken as long as the woman wishes (until the package is finished). While taking the drug from the second package, a woman may experience spotting or breakthrough uterine bleeding. Janine should be resumed from a new package after the usual 7-day break.

To postpone the day of the onset of menstruation to another day of the week, a woman should shorten the next break in taking pills for as many days as she wants. The shorter the interval, the higher the risk that she will not have withdrawal bleeding and in the future will have spotting spotting and breakthrough bleeding while taking the second pack (just as in the case when she would like to delay the onset of menstruation).

Additional information for special categories patients

For children and adolescents, Janine is indicated only after the onset of menarche.

After the onset of menopause, Janine is not indicated.

The drug Janine is contraindicated in women with severe liver disease until the liver function tests return to normal.

Side effects

• vaginitis;
• salpingo-oophoritis (adnexitis);
• urinary tract infections;
• cystitis;
• mastitis;
• cervicitis;
• fungal infections;
• candidiasis;
• herpetic lesions of the oral cavity;
• viral infections;
• uterine fibroids;
• anorexia;
• anemia;
• gastritis;
• enteritis;
• dyspepsia;
• eczema;
• psoriasis;
• hyperhidrosis;
• myalgia;
• limb pain;
• dysplasia of the cervix;
• cysts of the uterine appendages;
• pain in the uterine appendages;
• chest pain;
• peripheral edema;
• flu-like symptoms;
• fatigue;
• asthenia;
• feeling unwell;
• headache;
• dizziness;
• migraine.

Contraindications

Janine should not be used in the presence of any of the conditions / diseases listed below. If any of these conditions develop for the first time while taking it, the drug should be stopped immediately.

• the presence of thrombosis (venous and arterial), currently or in history (for example, deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders);
• the presence at present or in the history of conditions preceding thrombosis (for example, transient ischemic attacks, angina pectoris);
• diabetes mellitus with vascular complications;
• a current or history of migraine with focal neurological symptoms;
• the presence of severe or multiple risk factors for venous or arterial thrombosis (including complicated lesions of the valvular apparatus of the heart, atrial fibrillation, diseases of the cerebral or coronary arteries of the heart, uncontrolled arterial hypertension, serious surgery with prolonged immobilization, smoking over the age of 35 years);
• liver failure and severe liver disease (before normalization of liver function tests);
• the presence or history of pancreatitis with severe hypertriglyceridemia;
• the presence or history of benign or malignant liver tumors;
• identified hormone-dependent malignant diseases of the genitals or mammary glands or suspicion of them;
• vaginal bleeding of unknown origin;
• pregnancy or suspicion of it;
• breastfeeding period;
• hypersensitivity to the components of the drug.

Application during pregnancy and lactation

Janine is not prescribed during pregnancy and during breastfeeding.

If pregnancy is detected while taking Janine, the drug should be canceled immediately. However, extensive epidemiological studies have not revealed an increased risk of developmental defects in children, born to women who received sex hormones before pregnancy, or teratogenic action, when sex hormones were taken inadvertently in early dates pregnancy.

Taking combined oral contraceptives can reduce the amount of breast milk and change its composition, therefore, their use is contraindicated during lactation. Small amounts of sex steroids and / or their metabolites can be excreted in milk.

special instructions

Before starting or resuming the use of the drug Janine, it is necessary to familiarize yourself with the life history, family history of the woman, conduct a thorough general medical (including measurement of blood pressure, heart rate, determination of body mass index) and gynecological examination, including examination of the mammary glands and cytological examination of scraping from the cervix (test for Pap test), exclude pregnancy. The volume of additional studies and the frequency of follow-up examinations are determined individually. Usually, control examinations should be carried out at least once a year.

A woman should be informed that Janine does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Women with hypertriglyceridemia (or a family history of this condition) may have an increased risk of developing pancreatitis while taking combined oral contraceptives.

Although a small increase in blood pressure has been described in many women taking combined oral contraceptives, clinically significant increases were rarely observed. However, if a persistent, clinically significant increase develops while taking combined oral contraceptives. blood pressure, these drugs should be discontinued and treatment of arterial hypertension should be started. Taking combined oral contraceptives can be continued if normal blood pressure values ​​are achieved with the help of antihypertensive therapy.

Although combined oral contraceptives may have an effect on insulin resistance and glucose tolerance, there is no need to change the therapeutic regimen in patients diabetes mellitus using low-dose combined oral contraceptives (less than 50 mcg ethinyl estradiol). However, women with diabetes should be closely monitored while taking combined oral contraceptives.

The effectiveness of combined oral contraceptive drugs may be reduced by skipping pills, with vomiting and diarrhea, or as a result of drug interactions.

Effects on the menstrual cycle

While taking combined oral contraceptives, irregular bleeding (spotting spotting or breakthrough bleeding) may occur, especially during the first months of use. Therefore, assessment of any irregular bleeding should only be done after an adaptation period of approximately three cycles. If irregular bleeding recurs or develops after previous regular cycles, a thorough examination should be carried out to rule out malignant neoplasms or pregnancy.

In some women, withdrawal bleeding may not develop during a break in taking pills. If combined oral contraceptives are taken as directed, the woman is unlikely to be pregnant. However, if before this combined oral contraceptives were taken irregularly or if there are no two withdrawal bleeding in a row, pregnancy should be excluded before continuing to take the drug.

Impact on the performance of laboratory tests

Taking combined oral contraceptives can affect the results of some laboratory tests, including indicators of liver, kidney, thyroid, adrenal gland function, plasma transport proteins, carbohydrate metabolism, coagulation and fibrinolysis parameters. Changes usually do not go beyond the normal range.

Influence on the ability to drive vehicles and use mechanisms

Not found.

Drug interactions

The interaction of oral contraceptives with other drugs can lead to breakthrough bleeding and / or a decrease in contraceptive reliability.

According to some studies, some antibiotics (for example, penicillins and tetracycline) can reduce the intestinal-hepatic circulation of estrogens, thereby lowering the concentration of ethinyl estradiol.

While taking any of the above medicines a woman should additionally use a barrier method of contraception (for example, a condom).

Dienogest is a cytochrome P450 (CYP) 3A4 substrate. Known CYP3A4 inhibitors such as azole antifungal drugs(eg, ketoconazole), cimetidine, verapamil, macrolides (eg, erythromycin), diltiazem, antidepressants, and grapefruit juice may increase plasma levels of dienogest.

While taking antibiotics (with the exception of rifampicin and griseofulvin) and within 7 days after their cancellation, you should additionally use a barrier method of contraception. If the period of using the barrier method of protection ends later than the tablets in the package, you need to move on to the next package of Zhanin without the usual interruption in taking the tablets.

Combined oral contraceptives can interfere with the metabolism of other drugs, resulting in an increase (eg, cyclosporine) or a decrease (eg, lamotrigine) plasma and tissue concentrations.

Analogues of the drug Janine

Structural analogues for the active substance:

• Silhouette

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.